Ongoing Research

Neuro-EDS Phenotype Project (Brown + Atria)

In collaboration with Brown University and the Atria Health Institute, this program seeks to define a neurological phenotype within hypermobile connective tissue disorders through integrated clinical, imaging, physiologic, and outcome-based investigations.

Cervicomedullary Syndrome (CMS) Diagnostic Framework

Developing standardized clinical and research tools to characterize cervicomedullary syndrome and establish correlations with neuroanatomy, imaging findings, and treatment outcomes.

Legacy Registry and Phenomic Data Platform

Transforming more than a decade of clinical observations into structured, analyzable datasets to identify reproducible patterns, define clinical phenotypes, and advance precision medicine approaches in Neuro-EDS.

A Phenotype–Endotype Framework for Neuro-EDS (Brown + Atria)

Establish a biological framework for classifying Neuro-EDS by integrating clinical phenotypes, underlying disease mechanisms (endotypes), and objective clinical verifiers.

Craniospinal Biomechanics Research (Northeastern)

In collaboration with Northeastern University, this program investigates the biomechanical mechanisms underlying craniocervical instability, neural deformation, and neurologic dysfunction.

Bone Quality and Skeletal Endotype Study

Characterizing bone health, trabecular microarchitecture, and craniovertebral morphology using DEXA, Trabecular Bone Score (TBS), CT morphometrics, and clinical outcomes.

Craniovertebral Morphometrics and Bone Morphology (Brown + Atria)

Studying the occipital condyles, atlas (C1), axis (C2), skull base, and styloid processes to better understand structural variation and its influence on disease expression and treatment outcomes.

Craniocervical Fusion Outcomes Program

Evaluating long-term outcomes, quality of life, fusion success, and predictors of treatment response following craniocervical fusion.

Venous Disorders Program (Toronto)

In collaboration with the University of Toronto, investigating jugular venous compression, venous outflow disorders, and novel surgical approaches including CT transverse process resection.

Styloidogenic Disease and Eagle Syndrome Outcomes

Characterizing the neurologic, autonomic, vascular, and surgical manifestations of Eagle syndrome and related styloidogenic disorders.

Wound Healing and Tissue Repair (Mount Sinai)

In collaboration with the Icahn School of Medicine at Mount Sinai, this program investigates tissue fragility, reconstructive techniques, wound healing, and perioperative strategies aimed at reducing complications and improving surgical outcomes in connective tissue disorders.

Neuroimmune and Mast Cell Research

Investigating neuroinflammatory mechanisms, mast cell activation syndrome, and perioperative management in Neuro-EDS.

C2 Dorsal Root Ganglion Translational Research (Clemson)

In collaboration with Clemson University, utilizing surgically obtained tissue specimens to identify molecular signatures, biomarkers, and therapeutic targets.

Label-Free Microscopy and Tissue Biology (MIT)

In collaboration with MIT, employing advanced nonlinear label-free microscopy to study brain, neural, and connective tissue biology and the molecular mechanisms underlying Neuro-EDS.